Luzerne is a borough located 5 miles north of Wilkes Barre in Luzerne County, Pennsylvania, United States. The population was 2,703 at the time of the 2020 census. The community was first settled in 1807. It was later incorporated as a borough in 1882. Like Luzerne County, the borough was named after Chevalier de la Luzerne, a French diplomat.