Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the ...

Science DNA breaks are toxic lesions for the cell. In order to repair these breaks, it is necessary, starting from the break ends, to find a homologous sequence within the vastness of the genome. In ...

Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy ...

The study helps partly explain why: the metabolic enzyme IMPDH2 relocates to the nucleus of TNBC cells to assist in DNA repair processes. "IMPDH2 acts like a mechanic in the cell's nucleus, ...

Metabolic enzymes, typically associated with energy production, are now discovered to also play essential roles in the nucleus, such as orchestrating cell division and DNA repair. This breakthrough, ...

Studies suggest the cell is more interconnected than previously thought, opening up "exciting possibilities for science and medicine." ...

Unraveling DNA polymerase’s activity can help scientists better understand DNA replication and repair and explore how these processes fail and lead to diseases, such as cancer. “This finding [happened ...

When not undergoing replication, DNA molecules float freely within the cytoplasm of a cell. This makes them available to the ...

Crispr has already secured a historic first approval for a CRISPR/Cas9 drug and has several more potential blockbuster ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

Francesca Mattiroli is a group leader at the Hubrecht Institute since January 2018. Her group investigates chromatin dynamics during DNA replication and repair. The Mattiroli group uses biochemical ...

Bacteria frequently encounter adverse environmental conditions, such as nutrient scarcity and antibiotic exposure, which can induce DNA damage ...